Filippo, B., Granchi, D., Roatti, G., Merlini, L., Sabattini, T., & Baldini, N. (2017). Alpha-lipoic acid after median nerve decompression at the carpal tunnel: A randomized controlled trial. The Journal of Hand Surgery, 4, 236–42.
The Skinny – A double-blind randomized controlled study was performed. Sixty-four patients were randomly assigned into two groups after a median nerve decompression. Thirty-two patients took the alpha-lipoic acid (ALA) while the other 32 received the placebo pill.
In The Weeds – The outcome measures utilized were Boston Carpal Tunnel score, 2-point discrimination, and presence or absence of pillar pain, use of analgesics beyond post-op day 2 and sensory and motor conduction velocities. This was assessed at 3 months post-op.
Bringing it Home – ALA did not improve nerve conduction velocity or Boston Carpal Tunnel score significantly. Taking ALA did reduce the incidence of pillar pain and static 2-point discrimination improved in both groups.
Taking ALA for 40 days after carpal tunnel surgery can lower the incidence of Pillar Pain. The study size was relatively small. The outcome measures of pain and two-point discrimination test are relatively subjective measures. The ALA treatment was well tolerated by the study participants. A larger study is needed to confirm these findings.
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