Does Taking an Alpha-lipoic for 40 days after Carpal Tunnel Release decrease the likelihood of developing Pillar Pain?
Filed under Uncategorized
Filippo, B., Granchi, D., Roatti, G., Merlini, L., Sabattini, T., & Baldini, N. (2017). Alpha-lipoic acid after median nerve decompression at the carpal tunnel: A randomized controlled trial. The Journal of Hand Surgery, 4, 236–42.
The Skinny – A double-blind, randomized controlled study was performed. Sixty-four patients were randomly assigned into two groups after median nerve decompression. Thirty-two patients took the alpha-lipoic acid (ALA), while the other 32 received the placebo pill.

In The Weeds – The outcome measures utilized were Boston Carpal Tunnel score, 2-point discrimination, presence or absence of pillar pain, use of analgesics beyond post-op day 2, and sensory and motor conduction velocities. These measures were assessed at three months post-op.
Bringing it Home – ALA did not significantly improve nerve conduction velocity or Boston Carpal Tunnel score. Taking ALA did reduce pillar pain, and static 2-point discrimination improved in both groups.

Taking ALA for 40 days after carpal tunnel surgery can lower the incidence of Pillar Pain. The study size was relatively small, and the outcome measures of pain and two-point discrimination test are somewhat subjective measures. The ALA treatment (pillar pain treatment) was well tolerated by the study participants. A larger study is needed to confirm these findings.
More To Read
Top 5 DIP Flexion Exercises
By: Tori Rhodes Lately, we’ve had a handful of patients roll through our clinic with pretty significant limitations to DIP flexion. So, we’ve collected a selection of go-to exercises for these individuals. We’ve included a few of those here. From cat bites and fracture sites to mallet fingers and skin grafts, many individuals who are…
Wrist Fractures and Marijuana Use: What are the complications?
Title: Marijuana use and complications with healing after distal radius wrist fracture Article: Livesey, M. G., Bains, S. S., Stern, J. M., Chen, Z., Dubin, J. A., Monárrez, R., … & Ingari, J. V. (2025). Cannabis use in patients with distal radius fractures: a moment of unity?. Hand, 20(2), 263-268. The skinny The impact of tobacco use…
Increase Shoulder Range by Improving Scapulohumeral Rhythm
Scapulohumeral rhythm is often the key component when treating shoulder conditions and the lack of total shoulder range of motion. This may also be a critical component to prevent shoulder conditions during the rehabilitation of other upper extremity conditions such as distal radius fractures, tendon injuries, and elbow injuries. Scapulohumeral rhythm is the rhythm in…
What is the real job of the Lumbricals?
Crowley, J. S., Meunier, M., Lieber, R. L., & Abrams, R. A. (2020). The Lumbricals Are Not the Workhorse of Digital Extension and Do Not Relax Their Own Antagonist. The Journal of Hand Surgery. The Skinny: What do the lumbricals do? There is a long-standing belief that the lumbricals act as a counterforce to the…
Sign-up to Get Updates Straight to Your Inbox!
Sign up with us and we will send you regular blog posts on everything hand therapy, notices every time we upload new videos and tutorials, along with handout, protocols, and other useful information.