Does Taking an Alpha-lipoic for 40 days after Carpal Tunnel Release decrease the likelihood of developing Pillar Pain?
Filed under Uncategorized
Filippo, B., Granchi, D., Roatti, G., Merlini, L., Sabattini, T., & Baldini, N. (2017). Alpha-lipoic acid after median nerve decompression at the carpal tunnel: A randomized controlled trial. The Journal of Hand Surgery, 4, 236–42.
The Skinny – A double-blind, randomized controlled study was performed. Sixty-four patients were randomly assigned into two groups after median nerve decompression. Thirty-two patients took the alpha-lipoic acid (ALA), while the other 32 received the placebo pill.

In The Weeds – The outcome measures utilized were Boston Carpal Tunnel score, 2-point discrimination, presence or absence of pillar pain, use of analgesics beyond post-op day 2, and sensory and motor conduction velocities. These measures were assessed at three months post-op.
Bringing it Home – ALA did not significantly improve nerve conduction velocity or Boston Carpal Tunnel score. Taking ALA did reduce pillar pain, and static 2-point discrimination improved in both groups.

Taking ALA for 40 days after carpal tunnel surgery can lower the incidence of Pillar Pain. The study size was relatively small, and the outcome measures of pain and two-point discrimination test are somewhat subjective measures. The ALA treatment (pillar pain treatment) was well tolerated by the study participants. A larger study is needed to confirm these findings.
More To Read
Carpal Tunnel Treatment: Splinting Only vs Splinting & Conservative Treatment
Short-term clinical outcome of orthosis alone vs combination of orthosis, nerve, and tendon gliding exercises and ultrasound therapy for treatment of carpal tunnel syndrome. Sim, Sze En et al. Journal of Hand Therapy, Volume 32, Issue 4, 411 – 416 The Skinny- Carpal tunnel syndrome (CTS) is the most common compression neuropathy. Compression of the…
New Distal Bicep Tendinopathy Provocative Test for Hand Therapist
Caekebeke, P., Schenkels, E., Bell, S. N., & van Riet, R. (2021). Distal biceps provocation test. The Journal of Hand Surgery. The Skinny: These surgeons were looking for a provocative test for distal bicep tendinopathy (distal biceps tendonitis test), specifically partial tears, that was more sensitive and specific. Complete tears are more easily tested in…
Article Review: Use of Paper Tape for Scars
Use of Paper Tape for Scars (What is scar tape?) O’Reilly, S, Crofton, E., Brown, J., Strong, J., & Ziviani, J. (2021). Use of tape for the management of hypertrophic scar development: A comprehensive review. Scars, Burns & Healing, 7, 1–17 DOI: 10.1177/20595131211029206 The Skinny The authors looked to do a review of the current literature…
Our Favorite Mallet Finger Splints
By: Josh MacDonald Fabricating a custom splint for a mallet finger injury is challenging. Fingers are tiny and they have small tolerances for errors and adjustments with custom splints. Making a splint for a mallet finger injury is probably the hardest type of finger splint for a therapist to make. Treatment recommendations vary, with some…
Sign-up to Get Updates Straight to Your Inbox!
Sign up with us and we will send you regular blog posts on everything hand therapy, notices every time we upload new videos and tutorials, along with handout, protocols, and other useful information.